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BIOLOGICAL ACTION OF HORMONES

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 1. Glucocorticoids: structure of cortisol, target tissues, effects on metabolism and functions.  Hyper- and hypoproduction of the hormones.  2. Mineralocorticoids: structure of aldosterone, target tissues, biological effects. Hyper- and  hypoproduction of the hormones.  3. Female sex hormones: structure of estradiol and progesterone, target tissues, effects on  metabolism and functions. Hyper- and hypoproduction of the hormones.  4. Male sex hormones: structure of testosterone, target tissues, effects on metabolism and  functions. Hyper- and hypoproduction of the hormones.  5. Hormones of hypothalamus and hypophysis, their biological action. Growth hormone,  adrenocorticotropic hormone: target tissues, effects on metabolism. Hyper- and  hypoproduction of growth hormone.  6. Eicosanoids (prostaglandins, thromboxanes, leukotrienes) and their role in the regulation  of metabolism and functions.  7. Disorders of functions of endocrine glands: hyper- and hypoproduction of hormones. ADRENAL

HORMONE ACTION MECHANISM

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  CLASS № 29 HORMONE ACTION MECHANISM 1. General characteristics of hormones: properties, types of biological action. Classification of hormones on the chemical structure, site of formation, mechanism of action. Target tissues and the cell receptors of hormones. 2. Mechanisms of action of hormones binding with the membrane receptors. Second messengers: cyclic purine nucleotides, calcium ions, products of hydrolysis of phosphatidylinositol. Diversity of protein kinases and their role in transmission of hormonal signal. 3. Mechanism of action of hormones binding with the intracellular receptors. 4. Thyroid hormones: structure, target tissues, biological effects. Hyper- and hypoproduction of the hormones. 5. Parathyroid hormone, calcitonin: target tissues, biological effects. Hyper- and hypofunction of parathyroid hormone. 6. Pancreatic hormones: insulin, glucagon. Target tissues, biological effects. Hyper- and hypoproduction of the hormones. 7. Adrenaline and noradrenal